A 70-year-old woman was seen in this hospital because of vaginal bleeding. An endometrial-biopsy specimen showed a poorly differentiated malignant neoplasm that was suggestive of mixed müllerian tumor (carcinosarcoma). A diagnostic and therapeutic procedure was performed.

A 6-year-old girl was admitted to this hospital because of bone and joint pain for 1 year and recent onset of fever and abdominal distention. Imaging revealed a mass in the abdominal and pelvic region and lesions in the liver, kidneys, and multiple bones.

A 52-year-old woman was seen in the thyroid clinic of this hospital because of a mass in the neck. Imaging revealed abnormal cervical lymph nodes and two thyroid nodules with calcifications. A diagnostic procedure was performed.

Presentation of Case

Dr. Kimberly G. Blumenthal (Medicine): A 34-year-old woman, 2.5 months post partum, was admitted to this hospital because of episodes of altered mental status.

The patient had been well until approximately 3 months before admission, ...

A 54-year-old man had transient then persistent partial loss of vision. Images of the brain showed two adjacent masses in the left occipital and posterior parietal regions. A diagnostic procedure was performed.

A 32-year-old woman noted a crease in her right breast. Imaging studies showed a suspicious mass, and a biopsy specimen revealed infiltrating ductal carcinoma, positive for HER2. Staging showed liver lesions consistent with metastases. Management decisions were made.

Presentation of Case

Dr. Sarah Gee (Dermatology): An 82-year-old man was admitted to this hospital because of persistent skin lesions on the hands.

The patient had a history of diabetes mellitus and recurrent hidradenitis suppurativa. Five weeks before ...

A 9-month-old boy had had recurrent episodes of tachypnea and respiratory distress since he was 5.5 months of age, with expiratory wheezing and fine crackles on auscultation, hyperinflation on chest radiography, and bilateral ground-glass opacities on CT.

A 75-year-old man was seen because of memory loss and episodes of near-syncope, with word-finding difficulty and unilateral twitching. MRI with contrast material revealed hyperintensity and mild expansion of the left hippocampus, without enhancement.

A 19-year-old man was admitted to this hospital because of recurrent pancreatitis, associated with alcohol use, beginning 6 months earlier. On examination, he was obese and had upper abdominal tenderness. Imaging studies showed normal pancreatobiliary anatomy.

Presentation of Case

A 55-year-old man was seen in the cancer center at this hospital because of stage IV non–small-cell lung cancer (NSCLC).

The patient had been well until approximately 5 months earlier, when headaches developed, followed by left-sided ...

A 7-year-old boy with tuberous sclerosis complex was seen because of an increasingly complex cyst in the left kidney, seen on serial imaging studies. A diagnostic procedure was performed.

A 62-year-old woman was seen at this hospital because of dyspnea, anemia, and paraspinal masses. Examination revealed splenomegaly. Laboratory studies revealed microcytic anemia. A diagnostic test result was received.

Presentation of Case

A 31-year-old man was seen in the outpatient cancer center at this hospital because of dysphagia and a mediastinal mass.

The patient had been well until approximately 3 months before this evaluation, when progressive difficulty ...

A 49-year-old man came to this hospital for management of adenocarcinoma of the rectum, associated with adenomatous polyps. Imaging showed a large tumor with extension beyond the muscularis propria and multiple enlarged lymph nodes.

A 32-year-old woman had seizures since childhood, myoclonus, and recent cognitive decline. Family members had an autosomal-dominant pattern of neurologic disease. Diagnostic testing was performed. Cognitive decline continued; the patient died 2 years later. An autopsy was performed.

A 35-year-old man was seen in the outpatient cancer center at this hospital because of adenocarcinoma of the cecum. Three weeks earlier, he had passed bright red blood in the stool. Imaging studies revealed a mass in the cecum and the peritoneal and omental nodules. Colonoscopic-biopsy specimens of the cecal mass revealed adenocarcinoma. There was no family history of cancer. A management decision was made.

A 29-year-old right-handed woman was seen in the neurology clinic of this hospital because of a 3-year history of involuntary flexion of the left hand and increasing difficulty moving the left foot. Examination revealed dystonic movements and posturing of the left arm, hand, and foot. Brain imaging was normal. During the next 2.5 years, symptoms gradually worsened, and difficulty swallowing and speaking developed. A diagnostic test was performed.