Follow Topic:

SpecialtyGeriatrics/Aging

Showing 1 to 20 of 334 Articles

Filter Results

By Topic: All Topics; Geriatrics/
Aging General (170); Osteoporosis (79); Dementia/
Alzheimer Disease (70); End-of-Life Care (17); Rehabilitation (13)

By Date: Past 10 years; Past 20 years; Past 50 years; Past 100 years; Complete archive (1812-present); Specific date range

Show Only Articles with CME

Sort By:

Interactive Medical Case
A Startling Decline
An 89-year-old man presented with changes in cognition and personality. Six months earlier, he began to require help managing his finances and operating his computer. His family observed that he had a poor memory for recent events and found it difficult to express himself. During the next few…
- February 9, 2012
- Vaidya A., Dolan B.M., Edlow B.L., Rinne M.L., McGinnis S.M.
- N Engl J Med 2012; 366:e11
- Free Full Text
- CME
An 89-year-old man was brought to the ER for evaluation of changes in his cognition and personality. He exhibited poor memory for recent events and difficulty expressing himself. Test your diagnostic and therapeutic skills at NEJM.org.
- Save
Editorial
Brain Stimulation, Learning, and Memory
Advances in electrophysiology and high-resolution brain imaging have improved our understanding of the neural circuitry of episodic memory, including differential contributions of the hippocampus and the rhinal cortices. These advances are timely: the aging of the human population makes the…
- February 9, 2012
- Black S.E.
- N Engl J Med 2012; 366:563 - 565
Advances in electrophysiology and high-resolution brain imaging have improved our understanding of the neural circuitry of episodic memory, including differential contributions of the hippocampus and the rhinal cortices. These advances are timely: the ...
- PDF
- Save
Clinical Problem-Solving
Worth a Second Look
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 72-year-old man presented to his…
- February 2, 2012
- Berzin T.M., Greenberger N.J., Levy B.D., Loscalzo J.
- N Engl J Med 2012; 366:463 - 468
A 72-year-old man presented to his physician for evaluation of fatigue and weight loss. Over the previous 8 months, the patient had lost 16 kg (35 lb) and had begun having up to 10 loose stools per day. There was no history of blood in the stool, fever, chills, or rash.
- PDF
- Save
Correspondence
Repeat Expansion in C9ORF72 in Alzheimer's Disease
To the Editor: Alzheimer's disease is the most common progressive neurodegenerative disorder and a leading cause of dementia in the elderly. The genetic causes of Alzheimer's disease are complex, and only four mendelian genes have indisputably been associated with the disease. Mutations in genes…
- January 19, 2012
- N Engl J Med 2012; 366:283 - 284
- Free Full Text
A hexanucleotide repeat expansion in the gene C9ORF72 has been implicated in the development of amyotrophic lateral sclerosis and frontotemporal dementia. The variant has also been found in a small percentage of patients with probable late-onset Alzheimer's disease.
- PDF
- Save
Original Article
Bone-Density Testing Interval and Transition to Osteoporosis in Older Women
Current osteoporosis management guidelines– recommend routine bone mineral density (BMD) screening with the use of dual-energy x-ray absorptiometry (DXA) scans for women 65 years of age or older, but no guidelines specify an osteoporosis screening interval that is based on data from longitudinal…
- January 19, 2012
- Gourlay M.L., Fine J.P., Preisser J.S., et al.
- N Engl J Med 2012; 366:225 - 233
- CME
This study analyzed the transition from normal BMD or osteopenia to osteoporosis; in women 67 years of age or older, the time for 10% to develop osteoporosis was approximately 15 years for normal BMD or mild osteopenia at baseline, 5 years for moderate osteopenia, and 1 year for advanced osteopenia.
- PDF
- Save
Images in Clinical Medicine
A Head Shot
Figure 1.
- December 29, 2011
- Safarova M.S. and Ezhov M.V.
- N Engl J Med 2011; 365:2519
- Free Full Text
Cranial CT imaging revealed a metal foreign body at the edge of the foramen magnum in an 85-year-old man who had been hit by a bullet 82 years earlier. There was no evidence of neural damage.
- PDF
- Save
Original Article
Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery
In the United States, more than 17 million red-cell units are collected annually, and 15 million units are transfused. Blood transfusions are frequently given to surgical patients and to the elderly. Yet, the indications for postoperative transfusion have not been adequately evaluated and remain…
- December 29, 2011
- Carson J.L., Terrin M.L., Noveck H., et al.
- N Engl J Med 2011; 365:2453 - 2462
- CME
This trial compared a restrictive hemoglobin threshold with a liberal threshold for blood transfusion among hip-surgery patients with risk factors for CVD. The liberal strategy resulted in more transfusions and did not reduce death or inability to walk independently.
- PDF
- Save
Editorial
Transfusion Thresholds in FOCUS
Even though red-cell transfusion is an accepted and widely used intervention, questions regarding which patients should receive transfusions and under what circumstances continue to spark debate. There has been limited evidence from clinical trials to inform policy. Meanwhile, concern about…
- December 29, 2011
- Barr P.J. and Bailie K.E.M.
- N Engl J Med 2011; 365:2532 - 2533
Even though red-cell transfusion is an accepted and widely used intervention, questions regarding which patients should receive transfusions and under what circumstances continue to spark debate. There has been limited evidence from clinical trials to ...
- PDF
- Save
Review Article
Mechanisms of Disease: Proprotein Convertases in Health and Disease
Secretory proteins, such as hormones, enzymes, and receptors, constitute a broad group of biochemically active molecules that are essential for cellular function. Post-translational processing of their precursor molecules, which occurs through endoproteolytic cleavage, results in the formation of…
- December 29, 2011
- Artenstein A.W. and Opal S.M.
- N Engl J Med 2011; 365:2507 - 2518
Proteases that process larger precursor proteins into smaller functional proteins are involved in a wide range of physiologic processes. Derangements in the function of these enzymes play a role in many diseases.
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 39-2011 — A Woman in Her 90s with Unilateral Ptosis
Presentation of Case. Dr. Xuemei Cai (Medicine): A woman in her 90s was seen in the emergency department at this hospital because of ptosis of the left eyelid. The patient had been in her usual health until 4 days earlier when, on awakening, she was unable to open her left eye. She reported no…
- December 22, 2011
- Venna N., Gonzalez R.G., Zukerberg L.R.
- N Engl J Med 2011; 365:2413 - 2422
A woman in her 90s came to the ER because of acute unilateral ptosis. During the next 8 weeks, weakness of the neck, fatigue, choking, and difficulty breathing developed, progressing to respiratory failure and death. An autopsy was performed.
- PDF
- Save
Perspective
Discussing Overall Prognosis with the Very Elderly
It's late in the day in the office of a busy primary care physician, who is relieved to see that his last patient is a woman who, though 86 years old, has multiple stable medical problems and is visiting for her annual exam. The patient is accompanied by her daughter, who helps her mother with…
- December 8, 2011
- Smith A.K., Williams B.A., Lo B.
- N Engl J Med 2011; 365:2149 - 2151
Though life expectancy inexorably decreases with advancing age, we tend to avoid discussing overall prognosis with elderly patients who have no dominant terminal illness. But we may thereby undercut patients' ability to make informed choices about their future.
- PDF
- Save
Special Article
Emergency Hospitalizations for Adverse Drug Events in Older Americans
Decreasing the number of preventable rehospitalizations by 20% by the end of 2013 is a goal of the $1 billion federal initiative Partnership for Patients, and the pursuit of this goal represents an opportunity to reduce harm to patients and reduce health care costs. Adverse drug events are a direct…
- November 24, 2011
- Budnitz D.S., Lovegrove M.C., Shehab N., Richards C.L.
- N Engl J Med 2011; 365:2002 - 2012
This national study estimated that nearly 100,000 elderly patients were hospitalized for adverse drug events annually from 2007 through 2009. Most resulted from use of common medications such as warfarin and insulin, and only 1% from medications designated as high-risk.
- PDF
- Save
Correspondence
Acutely Injured Patients on Dabigatran
To the Editor: Trauma remains the fourth leading cause of death in the United States, with 40,000 deaths annually in persons over the age of 65. U.S. trauma centers are seeing an increasing number of severely injured elderly patients, and hemorrhagic complications and head injuries account for a…
- November 24, 2011
- N Engl J Med 2011; 365:2039 - 2040
- Free Full Text
The new oral direct thrombin inhibitor, dabigatran, is proving to be problematic in acutely injured patients, since it may promote bleeding and its effect cannot be easily reversed.
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 36-2011 — A 93-Year-Old Woman with Shortness of Breath and Chest Pain
Presentation of Case. Dr. Pooja Agrawal (Emergency Medicine): A 93-year-old woman was seen in the emergency department at this hospital because of chest pain and shortness of breath. The patient had been in her usual state of health, with hypertension and chronic renal insufficiency, until the…
- November 24, 2011
- Senecal E.L., Rosenfield K., Caldera A.E., Passeri J.J.
- N Engl J Med 2011; 365:2021 - 2028
- Video
A 93-year-old woman was seen in the emergency department because of a 3-hour history of chest pain and shortness of breath. An electrocardiogram showed ST-segment elevations. A diagnostic procedure was performed.
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 34-2011 — A 75-Year-Old Man with Memory Loss and Partial Seizures
Presentation of Case. A 75-year-old physician was seen in an outpatient office at this hospital because of memory loss and episodes of near-syncope. The patient had been generally well, except for mild and gradual memory loss, until 7 months earlier, when episodes of diffuse tingling and a…
- November 10, 2011
- Cash S.S., Larvie M., Dalmau J.
- N Engl J Med 2011; 365:1825 - 1833
A 75-year-old man was seen because of memory loss and episodes of near-syncope, with word-finding difficulty and unilateral twitching. MRI with contrast material revealed hyperintensity and mild expansion of the left hippocampus, without enhancement.
- PDF
- Save
Clinical Implications of Basic Research
Can Age-Associated Memory Decline Be Treated?
Many older adults believe that their memory is not as good as it was when they were younger. An epidemiologic study in Finland documented that 76% of persons over the age of 60 years reported problems with their memory. Age-associated memory decline has been well studied and refers to changes in…
- October 6, 2011
- D'Esposito M. and Gazzaley A.
- N Engl J Med 2011; 365:1346 - 1347
Many older adults believe that their memory is not as good as it was when they were younger. An epidemiologic study in Finland documented that 76% of persons over the age of 60 years reported problems with their memory.¹ Age-associated memory decline has ...
- PDF
- Save
Special Article
End-of-Life Transitions among Nursing Home Residents with Cognitive Issues
Health care transitions, such as the hospitalization of nursing home residents, have the potential for fragmentation of care, changes in the management of chronic diseases, duplication of diagnostic workups, and medical errors.– Few previous reports have described health care transitions among…
- September 29, 2011
- Gozalo P., Teno J.M., Mitchell S.L., et al.
- N Engl J Med 2011; 365:1212 - 1221
Among nursing home residents with cognitive impairment, burdensome transitions between the nursing home and the hospital or hospice during the last months of life were common, varied according to state, and were associated with a poor quality of care.
- PDF
- Save
Perspective
Reducing Unnecessary Hospitalizations of Nursing Home Residents
It's a common scenario: a 90-year-old resident of a U.S. nursing home — call her Ms. B. — has moderately advanced Alzheimer's disease, congestive heart failure with severe left-ventricular dysfunction, and chronic pain from degenerative joint disease. She develops a nonproductive cough and a…
- September 29, 2011
- Ouslander J.G. and Berenson R.A.
- N Engl J Med 2011; 365:1165 - 1167
- Free Full Text
Studies suggest that many hospitalizations of U.S. nursing home residents are inappropriate, avoidable, or related to conditions that could be treated outside hospitals — and they cost over $4 billion per year. But the causes of these hospitalizations are complex.
- PDF
- Save
Perspective
Confronting Alzheimer's Disease
At the age of 69, a year after retiring from his practice as a Minneapolis trial lawyer, Mike Donohue noticed his driving skills deteriorating. His wife persuaded him to undergo a simulated driving examination. "I flunked it miserably," he recalled. Donohue consulted his physician, underwent tests,…
- September 22, 2011
- Okie S.
- N Engl J Med 2011; 365:1069 - 1072
As the number of Americans with Alzheimer's disease increases, efforts to achieve earlier and better diagnosis of dementia have become key components of state plans for confronting the epidemic and will probably figure into a mandated national Alzheimer's plan.
- PDF
- Save
Review Article
Franklin H. Epstein Lecture: Sirtuins, Aging, and Medicine
Foreword. Franklin H. Epstein, M.D. served the New England Journal of Medicine for more than 20 years. A keen clinician, accomplished researcher, and outstanding teacher, Dr. Epstein was Chair and Professor of Medicine at Beth Israel Deaconess Medical Center, Boston, where the Franklin H. Epstein,…
- June 9, 2011
- Guarente L.
- N Engl J Med 2011; 364:2235 - 2244
In this year's Franklin H. Epstein Lecture, Leonard Guarente summarizes the many biologic properties of the sirtuin family of deacetylases and explains why enhancement or inhibition of specific sirtuins may influence many common diseases and longevity.
- PDF
- Save

Page

Medical Meetings Conferences and Meetings

American Association for the Study of Liver Diseases

The following courses will be offered in Atlanta, unless otherwise indicated: "Hepatitis Single Topic Conference: HCV Direct Antiviral Agents (DAA): Concepts, Development and Optimal Use" (March 16 and 17); "The Henry M. and Lillian Stratton Basic Research Single Topic Conference: Mitochondria and Hepatotoxicity" (June 8 and 9); "Clinical Research Single Topic Conference: Acetaminophen Poisoning" (June 9 and 10); and "63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012" (Boston, Nov. 9-13).

Contact AASLD, 1001 North Fairfax St., Suite 400, Alexandria, VA 22314; or call (703) 299-9766; or see http://www.aasld.org .

More Medical Meetings

Trends: Most Viewed (Last Week)

Insulin-Induced Lipohypertrophy

February 2, 2012
A Startling Decline

February 9, 2012
Deep Sulcus Sign

February 9, 2012

More Trends

The New England Journal of Medicine

SpecialtyGeriatrics/Aging

Showing 1 to 20 of 334 Articles

Filter Results

A Startling Decline

Brain Stimulation, Learning, and Memory

Worth a Second Look

Repeat Expansion in C9ORF72 in Alzheimer's Disease

Bone-Density Testing Interval and Transition to Osteoporosis in Older Women

A Head Shot

Liberal or Restrictive Transfusion in High-Risk Patients after Hip Surgery

Transfusion Thresholds in FOCUS

Mechanisms of Disease: Proprotein Convertases in Health and Disease

Case 39-2011 — A Woman in Her 90s with Unilateral Ptosis

Discussing Overall Prognosis with the Very Elderly

Emergency Hospitalizations for Adverse Drug Events in Older Americans

Acutely Injured Patients on Dabigatran

Case 36-2011 — A 93-Year-Old Woman with Shortness of Breath and Chest Pain

Case 34-2011 — A 75-Year-Old Man with Memory Loss and Partial Seizures

Can Age-Associated Memory Decline Be Treated?

End-of-Life Transitions among Nursing Home Residents with Cognitive Issues

Reducing Unnecessary Hospitalizations of Nursing Home Residents

Confronting Alzheimer's Disease

Franklin H. Epstein Lecture: Sirtuins, Aging, and Medicine

Medical Meetings Conferences and Meetings

American Association for the Study of Liver Diseases

Trends: Most Viewed (Last Week)