(DOI: 10.1056/NEJMoa1515510)
This randomized comparison of low-dose and standard-dose alteplase in acute ischemic stroke did not establish noninferiority of low-dose alteplase for the primary outcome of death or disability at 90 days. Fewer patients had intracerebral hemorrhages in the low-dose group.
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(DOI: 10.1056/NEJMoa1603060)
In this double-blind, randomized trial involving 13,199 patients with ischemic stroke or transient ischemic attack, ticagrelor was not superior to aspirin in reducing the rate of stroke, myocardial infarction, or death at 90 days.
Six foods commonly associated with food allergy were introduced in the diets of children at 3 months or 6 months of age. Intention-to-treat analysis showed no benefit of early introduction with respect to the prevalence of food allergy; a per-protocol analysis showed a difference. (View Video.)
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Pain from disk herniation, the leading cause of sciatica, usually resolves within several weeks with conservative therapy. In patients with sciatica for 6 weeks, pain relief is faster with surgery than with conservative therapy; however, outcomes are similar at 1 year.
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A 47-year-old man presented to an urgent care ambulatory clinic with a 3-day history of swelling around his left eye and a sensation of tightness in his throat. It had become difficult for him to swallow solids, and he felt as though food was sticking in his throat.
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(DOI: 10.1056/NEJMoa1515510)
(DOI: 10.1056/NEJMe1605228)
(DOI: 10.1056/NEJMoa1603060)
(DOI: 10.1056/NEJMoa1513614)
