Data from the Global Burden of Disease study indicate that there were 319,400 deaths due to rheumatic heart disease and 33.4 million cases of rheumatic heart disease in 2015. The highest death and prevalence rates were found in Oceania, South Asia, and central sub-Saharan Africa.
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In this randomized, double-blind trial involving patients with type 2 diabetes at high risk for cardiovascular events, basal insulin degludec was noninferior to glargine with respect to major cardiovascular events.
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In this case, a woman with refractory diffuse large-B-cell lymphoma had a CNS recurrence that responded completely to anti-CD19 CAR T-cell therapy. After biopsy of a subsequent skin recurrence, the lesions cleared in association with an expansion of the CAR T cells in the blood.
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A 32-year-old man with a history of illicit drug use and a family history of premature heart disease presented with acute chest pain. What is the most likely diagnosis?
Vote and comment. Find the answers in the full text of the case, to be published on August 31. On Twitter use #NEJMCases.
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A secondary analysis of SPRINT, a trial involving patients with hypertension and high cardiovascular risk in which intensive therapy resulted in lower rates of cardiovascular events than standard therapy, showed that patient-reported outcomes were similar in the two groups.
In a cost-effectiveness analysis, intensive blood-pressure control rather than standard treatment (target, <120 mm Hg vs. <140 mm Hg) was associated with an incremental cost-effectiveness ratio of about $47,000 per quality-adjusted life-year gained.
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- No corrections published in this issue.
(DOI: 10.1056/NEJMsr1710032)
(DOI: 10.1056/NEJMp1707409)
