In this cluster-randomized trial in Uttar Pradesh, India, a coaching-based implementation of a WHO-based Safe Childbirth Checklist over a period of 8 months increased adherence to essential birth practices but did not reduce maternal or perinatal mortality or maternal morbidity.
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In this trial in patients with type 1 diabetes who were receiving insulin, the proportion of patients who achieved a glycated hemoglobin level lower than 7.0% and no severe hypoglycemia or diabetic ketoacidosis was larger in the sotagliflozin group than in the placebo group.
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In five patients with refractory ventricular tachycardia, stereotactic body radiation therapy was directed to the targeted site by means of electrocardiographic mapping, which resulted in a 99.9% reduction in the ventricular tachycardia burden.
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Although reducing unnecessary care is important, the missionary waste-hunting zeal of the “less is more” movement can obscure a complex evidence base, perpetuating an oversimplified narrative about waste’s magnitude, causes, and solutions.
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Kidney disease, which is a common complication of HIV infection and its treatment, may shorten the lifespan of affected patients. This review considers the breadth of conditions that may affect the kidneys in persons with HIV infection.
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A 20-year-old woman was evaluated for seizures and progressive dystonia, which she had had since she was 3 years of age. Her younger sister had a similar illness. Imaging studies showed areas of abnormal hyperintensity in the basal ganglia. A diagnostic test was performed.
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Policymakers have focused substantial energy on curbing opioid-prescribing rates. The challenge is designing effective opioid-prescription policies to stem the flood of overdoses without having to wait several years to accumulate additional evidence.
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(DOI: 10.1056/NEJMp1715962)
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(DOI: 10.1056/NEJMp1715962)
(DOI: 10.1056/NEJMp1714824)
(DOI: 10.1056/NEJMoa1714678)
(DOI: 10.1056/NEJMoa1711948)
