In a study designed to assess whether danazol could slow the rate of telomere attrition in a group of patients with short telomeres, 11 of 12 patients actually had telomere elongation over 24 months of therapy.
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(DOI: 10.1056/NEJMoa1508952)
An understanding of the early events in primary human immunodeficiency virus type 1 (HIV-1) infection is important to improve treatment and control the spread of the virus. This study describes early virologic and immunopathologic events in acute HIV-1 infection.
(DOI: 10.1056/NEJMoa1508419)
Genetic data show that a loss-of-function variant in ASGR1 is associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease.
In this study involving patients with new-onset postoperative atrial fibrillation who received either rate control or rhythm control, there was no significant difference in rates of hospitalization, complications, or persistent atrial fibrillation 60 days after onset.
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(DOI: 10.1056/NEJMoa1508952)
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